Abstract
A variety of novel heterocyclic compounds were synthesized and evaluated for MMP inhibition. Broad spectrum inhibition of MMPs 1, 2, 9, and 12 was found with pyridinone-based compounds while N-heterocyclic triazoles and tetrazoles were largely ineffective. A highly selective tetrazole inhibitor for MMP-2 was discovered.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Catalytic Domain / drug effects
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Combinatorial Chemistry Techniques
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Drug Design*
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Matrix Metalloproteinase Inhibitors*
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Matrix Metalloproteinases / metabolism
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Molecular Structure
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Pyridones / chemical synthesis*
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Pyridones / chemistry
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Pyridones / pharmacology*
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Structure-Activity Relationship
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Triazoles / chemical synthesis*
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Triazoles / chemistry
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Triazoles / pharmacology*
Substances
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Matrix Metalloproteinase Inhibitors
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Pyridones
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Triazoles
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Matrix Metalloproteinases